Impact of Particulate Matter Exposure and Aerobic Exercise on Circulating Biomarkers of Oxidative Stress, Antioxidant Status, and Inflammation in Young and Aged Mice

Exposure to particulate matter (PM) and exercise training can have antagonistic effects on inflammatory responses the balance between pro-oxidants antioxidants in body. However, underlying mechanisms of these remain unclear. This study aimed investigate PM exposure aerobic oxidative stress, antioxidant status, inflammation mice different ages. Two groups male C57BL/6 mice, comprising forty 1-month-old 12-month-old were exposed either or both for 8 weeks. led significantly higher 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) levels (p < 0.05) lower superoxide dismutase (SOD) catalase (CAT) activities age compared control groups. Conversely, 8-OHdG, MDA, IL-1β, IL-6, TNF-α SOD CAT receiving training, those PM. Moreover, young group showed IL-1β than group. did not vary old that received Our results suggest while could cause pro-oxidant/antioxidant imbalances responses, regular ameliorate negative effects, although with age. Nevertheless, anti-inflammatory countered by exposure, especially older mice.